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Volume 1 | Issue 1 | January - June 2017

Prevention of chemotherapy induced nausea and vomiting in pediatric cancer patients

Article 1, Volume 1, Issue 1, jan-june 2017, Page 16-22  PDF Download

Document type : Original Article

Author : Shubham Roy1, Rashi Kulshrestha 2, Abhishek Shankar 3,  Goura Kishor Rath 4, Vipin Kharade5

1Department of Pediatrics, VMMC & Safdarjung Hospital, Delhi, India

2Department of Radiation Oncology, Maulana Azad Medical College, Delhi. India

3Department of Preventive Oncology, Dr B.R.Ambedkar Institute Rotary Cancer Hospital, All India
Institute of Medical Sciences, Delhi, India

4Department of Radiation Oncology, Dr B.R.Ambedkar Institute Rotary Cancer Hospital, All India
Institute of Medical Sciences, Delhi, India

 

Abstract

Despite the relevant progress achieved in the last 20 years, vomiting and, especially, nausea, continue to be two of the most distressing side-effects of cancer chemotherapy. The goal of antiemetic therapy is to prevent nausea and vomiting associated with chemotherapy administration. The appropriate pharmacologic treatment should be chosen by evaluating the emetogenic risk of chemotherapy as a single agent or as combination therapy. For most children, receiving any chemotherapy that has emetogenic potential, a 5-hydroxytryptamine-3 (5-HT3) receptor antagonist should form the backbone of antiemetic therapy.Nausea and vomiting in pediatric cancer patients can be multi-factorial. Evaluation of symptoms should reflect this. Nausea and vomiting can have structural, psychological, chemical, and metabolic or a combination of origins. Nausea and vomiting is a troublesome side effects of chemotherapy and when antiemetic prophylaxis is not adequate, it affects the compliance of the treatment. This is a mini review on different aspects of chemotherapy induced nausea and vomiting in pediatric patients.

 

Keywords: Chemotherapy, Nausea, Vomiting, Pediatric cancer. 

 

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